BDBM50132475 CHEMBL3634612::US9751873, Example 67

SMILES FC(F)[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1ccc(cc1F)N1CCC(CC1)n1cnnc1

InChI Key InChIKey=FATTZAJUJHTOCQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50132475   

TargetNuclear receptor ROR-gamma(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50132475(CHEMBL3634612 | US9751873, Example 67)
Affinity DataIC50: 26nMAssay Description:Displacement of 25-[3H]hydroxycholesterol from N-terminal 6xHis-GST-tagged human RORc ligand binding domain expressed in Escherichia coli after 3 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50132475(CHEMBL3634612 | US9751873, Example 67)
Affinity DataIC50: 26nMAssay Description:Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent