BDBM50132080 Biphenyl-4-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide; oxalic acid::CHEMBL112065::CHEMBL129483

SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(cc2)-c2ccccc2)CC1

InChI Key InChIKey=OJZXUFDBDMQATJ-UHFFFAOYSA-N

Data  8 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50132080   

TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataEC50:  12nMAssay Description:Partial agonist activity at human dopamine D2long receptor expressed in CHO cells assessed as induction of [3H]thymidine incorporation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Biocon-Bristol Myers Squibb Research and Development Centre

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Biocon-Bristol Myers Squibb Research and Development Centre

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataIC50: 42nMAssay Description:Inhibition of hERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]spiroperidol from cloned human dopamine receptor D3 in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]spiperone from wild type human dopamine D3 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataKi:  2.85nMAssay Description:Binding affinity for human dopamine receptor D3 by displacing [125I]iodosulpiride expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataKi:  75nMAssay Description:Binding affinity for human dopamine receptor D2 by displacing [125I]iodosulpiride expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Pig)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50132080(CHEMBL112065 | CHEMBL129483 | Biphenyl-4-carboxyli...)
Affinity DataKi:  570nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed