BDBM50131995 (E)-3-(4-hydroxybenzylidene)indolin-2-one::3-(4-Hydroxy-benzylidene)-1,3-dihydro-indol-2-one::3-(4-hydroxybenzylidene)indolin-2-one::CHEMBL103307

SMILES Oc1ccc(\C=C2\C(=O)Nc3ccccc23)cc1

InChI Key InChIKey=PLAOAGFXNCEZMZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50131995   

LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, PfmrkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ABL by ELISA-based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetTubulin beta chain(Pig)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of porcine brain tubulin polymerization by GTP-induced assemblyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Volgograd State Medical University

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human GSK3beta (636 to 661 residues) assessed as reduction in human muscle glycogen synthase type 1 fragment phosphorylatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed