BDBM50131844 CHEMBL3633349

SMILES COc1cc(ccc1Nc1ncc2c(n1)n(-c1cccc(NC(=O)C=C)c1)c1nccn1c2=O)N1CCC(CC1)N(C)C

InChI Key InChIKey=NKHMICLDWIUZLX-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50131844   

TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131844(CHEMBL3633349)
Affinity DataKd:  310nMAssay Description:Binding affinity to wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131844(CHEMBL3633349)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed