BDBM50131809 CHEMBL3634342
SMILES C[C@@]1(N=C(N)CO[C@@H]1F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
InChI Key InChIKey=XHHSQAOCTYSLLM-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50131809
Affinity DataIC50: 8.10nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by sandw...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human recombinant CYP2D6 by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:Inhibition of BACE1 (unknown origin) using APP Swedish mutant harboring Lys-Met/Asn-Leu mutation in beta-secretase cleavage site as substrate by FRET...More data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells transfected with APP695 protein assessed as reduction in amyloid beta (1 to 42) levels after 18 hrs by sand...More data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP derived polypeptide harboring Lys-Met/Asn-Leu mutation as substrate by FRET assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceutica
Curated by ChEMBL
Janssen Pharmaceutica
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cell membranes by radioligand binding assayMore data for this Ligand-Target Pair