BDBM50131688 (E)-4-(3,5-dimethoxystyryl)phenol::3,5-Dimethoxy-4'-hydroxyl-trans-stilbene::4'-hydroxy-3,5-dimethoxy stilbene::4-(3,5-dimethoxystyryl)phenol::4-[(E)-2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol::4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol::CHEMBL83527::E 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol::Pterostilben::Pterostilbene

SMILES COc1cc(cc(c1)OC)/C=C/c2ccc(cc2)O

InChI Key InChIKey=VLEUZFDZJKSGMX-UHFFFAOYSA-N

Data  3 KI  14 IC50  2 Kd  1 EC50

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50131688   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 530nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of recombinant human 5-LOX using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 5.99E+3nMAssay Description:Inhibition of recombinant human COX-2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as dissociation constant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to recombinant N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as quenching...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 9.32E+3nMAssay Description:Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 9.32E+3nMAssay Description:Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 3.91E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 700nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) using N-methyldihydronicotinamide as co-substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 4.20E+4nMAssay Description:Antiproliferative activity against MDR human HL60R cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antiproliferative activity against human K562 cell line expressing Bcr-AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataEC50:  3.60E+3nMAssay Description:Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 7.50E+3nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase of intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 820nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataKi:  570nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataKi:  910nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of recombinant N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as acid mediated a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)