BDBM50131365 7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-enyl)-piperazin-1-ylmethyl]-3a,4-dihydro-3H-chromeno[4,3-c]isoxazole::CHEMBL327875

SMILES COc1cc2OCC3C(CN4CCN(C\C=C(/C)c5ccccc5)CC4)ON=C3c2cc1OC

InChI Key InChIKey=YMYZKGIHGMHZDL-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50131365   

TargetAlpha-2C adrenergic receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131365(7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-enyl)-piper...)
Affinity DataKi:  0.600nMAssay Description:In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131365(7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-enyl)-piper...)
Affinity DataKi:  1.40nMAssay Description:In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]rauwolscineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131365(7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-enyl)-piper...)
Affinity DataKi:  10nMAssay Description:In vitro binding affinity towards rat serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131365(7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-enyl)-piper...)
Affinity DataKi:  31nMAssay Description:In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]rauwolscineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed