BDBM50131267 CHEMBL3634759::US9260425, 222

SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(c1)N1CCC[C@@H](N)C1

InChI Key InChIKey=UKAGZEMTXTYYHX-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50131267   

TargetSerine/threonine-protein kinase pim-3(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50131267(CHEMBL3634759 | US9260425, 222)
Affinity DataKi:  0.290nMAssay Description:Inhibition of Pim3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genetech

US Patent
LigandPNGBDBM50131267(CHEMBL3634759 | US9260425, 222)
Affinity DataKi:  0.387nMpH: 7.2Assay Description:PIM-1, PIM-2, and PIM-3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Genetech

US Patent
LigandPNGBDBM50131267(CHEMBL3634759 | US9260425, 222)
Affinity DataKi:  0.390nMAssay Description:Inhibition of Pim1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50131267(CHEMBL3634759 | US9260425, 222)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMed