BDBM50130703 CHEMBL3632743

SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12

InChI Key InChIKey=SKMYKZYXPMRFNN-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50130703   

LigandPNGBDBM50130703(CHEMBL3632743)
Affinity DataIC50: 1.53E+6nMAssay Description:Inhibition of Mnk1 (unknown origin) using eIF4E-derived (D 202 TATKSGSTTKNR 214) peptide as substrate incubated for 90 mins by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50130703(CHEMBL3632743)
Affinity DataIC50: 2.19E+5nMAssay Description:Inhibition of His-tagged Mnk2 (unknown origin) using eIF4E-derived (D 202 TATKSGSTTKNR 214) peptide as substrate incubated for 90 mins by IMAP TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50130703(CHEMBL3632743)
Affinity DataKi:  110nMAssay Description:Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
LigandPNGBDBM50130703(CHEMBL3632743)
Affinity DataKi:  1.02E+3nMAssay Description:Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50130703(CHEMBL3632743)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of CDK2/cyclinA (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50130703(CHEMBL3632743)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of CDK9/cyclinT1 (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed