BDBM50130658 2-Fluoro-4-[5-(4-fluoro-phenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridine::2-fluoro-4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridine::CHEMBL111403

SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(F)c1

InChI Key InChIKey=RRTXHGDCNJPJLH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50130658   

TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50130658(2-Fluoro-4-[5-(4-fluoro-phenyl)-2-methylsulfanyl-3...)
Affinity DataIC50: 559nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130658(2-Fluoro-4-[5-(4-fluoro-phenyl)-2-methylsulfanyl-3...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibitory activity against TNF-alpha release in PBM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130658(2-Fluoro-4-[5-(4-fluoro-phenyl)-2-methylsulfanyl-3...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 at 10 e-4 to 10 e-8 M concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130658(2-Fluoro-4-[5-(4-fluoro-phenyl)-2-methylsulfanyl-3...)
Affinity DataIC50: 300nMAssay Description:Inhibitory activity against induction of IL-1-beta release in PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed