BDBM50130346 3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid benzyl ester::CHEMBL316634

SMILES CN1C2CCC1[C@H]([C@H](C2)OC(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)OCc1ccccc1

InChI Key

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50130346   

TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130346(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataIC50: 2.20nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130346(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  48.4nMAssay Description:In vitro dopamine transporter binding affinity using [3H]WIN-35428 as radioligand was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130346(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  2.04E+3nMAssay Description:Binding affinity towards serotonin transporter using [3H]citalopram as radioligand was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130346(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  2.23E+3nMAssay Description:Binding affinity towards norepinephrine transporter using [3H]nisoxetine as radioligand was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130346(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataKi:  4.38E+3nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 using [3H]pirenzepine as radioligand was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed