BDBM50130177 2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one::CHEMBL312186

SMILES Oc1ccc2c(c1)oc1oc3cc(O)cc(O)c3c(=O)c21

InChI Key InChIKey=BBBAWACESCACAP-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50130177   

TargetEstrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50130177(2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one...)
Affinity DataIC50: 28nMAssay Description:Binding affinity towards human estrogen receptor alpha(ERalpha)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50130177(2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one...)
Affinity DataIC50: 1.70nMAssay Description:Binding affinity towards human estrogen receptor beta (ERbeta)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50130177(2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human 17beta-HSD1 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estrone and NADPH by scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50130177(2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one...)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50130177(2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human ERalpha expressed in yeast cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAryl hydrocarbon receptor(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50130177(2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one...)
Affinity DataEC50:  1.34E+3nMAssay Description:Agonist activity at human AHR expressed in yeast cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed