BDBM50130054 (R)-N-{(S)-2-(4-Cyano-phenyl)-1-[(S)-4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-ethyl}-3-phenyl-2-phenylmethanesulfonylamino-propionamide::(R)-N-{2-(4-Cyano-phenyl)-1-[(S)-(S)-4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-ethyl}-3-phenyl-2-phenylmethanesulfonylamino-propionamide::CHEMBL77142

SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(cc1)C#N)NC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)Cc1ccccc1)C(=O)c1nccs1

InChI Key InChIKey=ORJYLMNCIRRJGS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50130054   

TargetProthrombin(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130054((R)-N-{2-(4-Cyano-phenyl)-1-[(S)-(S)-4-guanidino-1...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against thrombin (IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130054((R)-N-{2-(4-Cyano-phenyl)-1-[(S)-(S)-4-guanidino-1...)
Affinity DataIC50: 340nMAssay Description:Inhibition of tissue coagulation factor VIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130054((R)-N-{2-(4-Cyano-phenyl)-1-[(S)-(S)-4-guanidino-1...)
Affinity DataIC50: 900nMAssay Description:Inhibition of coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130054((R)-N-{2-(4-Cyano-phenyl)-1-[(S)-(S)-4-guanidino-1...)
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against coagulation factor X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130054((R)-N-{2-(4-Cyano-phenyl)-1-[(S)-(S)-4-guanidino-1...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against thrombin (IIa).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130054((R)-N-{2-(4-Cyano-phenyl)-1-[(S)-(S)-4-guanidino-1...)
Affinity DataIC50: 340nMAssay Description:Inhibitory activity against tissue coagulation factor VII.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed