BDBM50129987 2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)carbamoyl)-4-(4-chlorophenyl)butyl(4-(2-methoxybenzyl)benzyl)phosphinic acid::CHEMBL308277::[4-(4-Chloro-phenyl)-2-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-butyl]-[4-(2-methoxy-benzyl)-benzyl]-phosphinic acid

SMILES CNC(=O)[C@@H](NC(=O)C(CCc1ccc(Cl)cc1)CP(O)(=O)Cc1ccc(Cc2ccccc2OC)cc1)C(C)(C)C

InChI Key InChIKey=VGXYGECPCDQSNI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50129987   

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 4.5nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed