BDBM50129889 1-[2-(3-Hydroxy-adamantan-1-ylamino)-acetyl]-pyrrolidine-2-carbonitrile::CHEMBL319819

SMILES O[C@]12C[C@@H]3C[C@H](C1)CC(C3)(C2)NCC(=O)N1CCC[C@H]1C#N

InChI Key

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50129889   

TargetDipeptidyl peptidase 4(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50129889(1-[2-(3-Hydroxy-adamantan-1-ylamino)-acetyl]-pyrro...)
Affinity DataIC50: 2.70nMAssay Description:Inhibitory activity against Dipeptidyl peptidase IV (DPP-IV) obtained from human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50129889(1-[2-(3-Hydroxy-adamantan-1-ylamino)-acetyl]-pyrro...)
Affinity DataIC50: 2.10E+5nMAssay Description:In vitro inhibitory activity against Post-proline cleaving enzyme (PPCE) obtained from human erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Rat)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50129889(1-[2-(3-Hydroxy-adamantan-1-ylamino)-acetyl]-pyrro...)
Affinity DataIC50: 2.30nMAssay Description:Inhibitory activity against Dipeptidyl peptidase IV (DPP-IV) obtained from rat plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50129889(1-[2-(3-Hydroxy-adamantan-1-ylamino)-acetyl]-pyrro...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50129889(1-[2-(3-Hydroxy-adamantan-1-ylamino)-acetyl]-pyrro...)
Affinity DataIC50: 5.00E+5nMAssay Description:In vitro inhibitory activity against Dipeptidyl peptidase II (DPP II) obtained form bovine kidney homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed