BDBM50129425 5-Fluoro-1H-indole-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide::CHEMBL68740::N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-5-fluoro-1H-indole-2-carboxamide

SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl

InChI Key InChIKey=IMCPEGAWOYJDMH-UHFFFAOYSA-N

Data  8 KI  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50129425   

TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Stimulation of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as stimulation of quinpirole-stimulated mitogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataIC50: 564nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of quinpirole-stimulated mitogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of quinpirole-stimulated mitogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataIC50: 52nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole-stimulated mitogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataIC50: 52nMAssay Description:Antagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor (unknown origin) expressed in HEK293 cells after 1 hr by liquid scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  0.520nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity towards rat Dopamine receptor D3 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]IABN as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D2 receptor (unknown origin) expressed in HEK293 cells after 1 hr by liquid scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  83nMAssay Description:Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]IABN as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  540nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  990nMAssay Description:Displacement of [125I]DOI from 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]DOI from 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed