BDBM50129276 CHEMBL3629737::US9464103, (6aR,10aS)-10a-(4-chlorobenzenesulfonyl)-1,4-difluoro-6',6'-dimethyl-6,6a,8,9,10,10a-hexahydrospiro[benzo[c]isochromene-7,3'-[1,5]dioxane]

SMILES CC1(C)OCC2(CCC[C@@]3([C@H]2COc2c(F)ccc(F)c32)S(=O)(=O)c2ccc(Cl)cc2)CO1

InChI Key InChIKey=KKFRXIHTRCQMHV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50129276   

TargetAmyloid-beta precursor protein [672-711](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50129276(US9464103, (6aR,10aS)-10a-(4-chlorobenzenesulfonyl...)
Affinity DataIC50: 66.6nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

LigandPNGBDBM50129276(US9464103, (6aR,10aS)-10a-(4-chlorobenzenesulfonyl...)
Affinity DataIC50: 67nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50129276(US9464103, (6aR,10aS)-10a-(4-chlorobenzenesulfonyl...)
Affinity DataIC50: 33nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50129276(US9464103, (6aR,10aS)-10a-(4-chlorobenzenesulfonyl...)
Affinity DataIC50: 12nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed