BDBM50129173 7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene::CHEMBL63788

SMILES CC1CC(C)(C)Nc2ccc-3c(COc4c(F)cc(F)cc-34)c12

InChI Key InChIKey=QWPDENUMNMUTHR-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50129173   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129173(7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H...)
Affinity DataEC50:  40nMAssay Description:Antagonistic activity at human progesterone receptor in CV-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129173(7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H...)
Affinity DataKi:  45nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129173(7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H...)
Affinity DataIC50: 147nMAssay Description:Inhibition of antagonist activity towards Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129173(7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H...)
Affinity DataIC50: 217nMAssay Description:Inhibition of human progesterone receptor activation in T47D human breast cancer cell.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed