BDBM50129171 9-Bromo-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::9-bromo-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline::CHEMBL62761

SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4c(F)cc(Br)cc-34)c12

InChI Key InChIKey=OFRWAMYYBARBJR-UHFFFAOYSA-N

Data  2 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50129171   

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129171(9-bromo-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-ch...)
Affinity DataIC50: 90nMAssay Description:Inhibition of antagonist activity towards Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129171(9-bromo-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-ch...)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of antagonist activity towards glucocorticoid (hGR) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129171(9-bromo-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-ch...)
Affinity DataEC50:  57nMAssay Description:Antagonistic activity at human progesterone receptor in CV-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129171(9-bromo-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-ch...)
Affinity DataIC50: 461nMAssay Description:Inhibition of human progesterone receptor activation in T47D human breast cancer cell.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129171(9-bromo-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-ch...)
Affinity DataKi:  12nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129171(9-bromo-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-ch...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed