BDBM50129165 2,2,4-Trimethyl-9-nitro-2,5-dihydro-1H-6-oxa-1-aza-chrysene::2,2,4-trimethyl-9-nitro-2,5-dihydro-1H-chromeno[3,4-f]quinoline::CHEMBL64294

SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccc(cc-34)[N+]([O-])=O)c12

InChI Key InChIKey=WFOHHEVAQLCSFM-UHFFFAOYSA-N

Data  2 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50129165   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129165(2,2,4-Trimethyl-9-nitro-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataEC50:  257nMAssay Description:Effective concentration for human progesterone receptor in T47D human breast cancer cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129165(2,2,4-Trimethyl-9-nitro-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibition of antagonist activity towards mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129165(2,2,4-Trimethyl-9-nitro-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataIC50: 60nMAssay Description:Inhibition of antagonist activity towards Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129165(2,2,4-Trimethyl-9-nitro-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataIC50: 689nMAssay Description:Inhibition of antagonist activity towards glucocorticoid (hGR) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129165(2,2,4-Trimethyl-9-nitro-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataEC50:  29nMAssay Description:Antagonistic activity at human progesterone receptor in CV-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129165(2,2,4-Trimethyl-9-nitro-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataIC50: 152nMAssay Description:Inhibition of human progesterone receptor activation in T47D human breast cancer cell.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129165(2,2,4-Trimethyl-9-nitro-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129165(2,2,4-Trimethyl-9-nitro-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed