BDBM50129163 7,9-Difluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::7,9-difluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline::CHEMBL418684

SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4c(F)cc(F)cc-34)c12

InChI Key InChIKey=IXAZIQYAFRPNHY-UHFFFAOYSA-N

Data  2 KI  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50129163   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129163(7,9-difluoro-2,2,4-trimethyl-2,5-dihydro-1H-chrome...)
Affinity DataIC50: 3.03E+3nMAssay Description:Inhibition of antagonist activity towards glucocorticoid (hGR) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129163(7,9-difluoro-2,2,4-trimethyl-2,5-dihydro-1H-chrome...)
Affinity DataIC50: 644nMAssay Description:Inhibition of antagonist activity towards human Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129163(7,9-difluoro-2,2,4-trimethyl-2,5-dihydro-1H-chrome...)
Affinity DataEC50:  244nMAssay Description:Effective concentration for human progesterone in T47D human breast cancer cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129163(7,9-difluoro-2,2,4-trimethyl-2,5-dihydro-1H-chrome...)
Affinity DataIC50: 86nMAssay Description:Inhibition of human progesterone in T47D human breast cancer cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129163(7,9-difluoro-2,2,4-trimethyl-2,5-dihydro-1H-chrome...)
Affinity DataEC50:  25nMAssay Description:Effective concentration for antagonistic activity towards human progesterone in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129163(7,9-difluoro-2,2,4-trimethyl-2,5-dihydro-1H-chrome...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129163(7,9-difluoro-2,2,4-trimethyl-2,5-dihydro-1H-chrome...)
Affinity DataKi:  14nMAssay Description:Binding towards human progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed