BDBM50129159 9-Bromo-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::9-bromo-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline::CHEMBL63870

SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccc(Br)cc-34)c12

InChI Key InChIKey=KRGAYZJXZMMOOH-UHFFFAOYSA-N

Data  2 KI  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50129159   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129159(9-bromo-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,...)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of antagonist activity towards glucocorticoid (hGR) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129159(9-bromo-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,...)
Affinity DataIC50: 395nMAssay Description:Inhibition of antagonist activity towards Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129159(9-bromo-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,...)
Affinity DataEC50:  45nMAssay Description:Antagonistic activity at human progesterone receptor in CV-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129159(9-bromo-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,...)
Affinity DataEC50:  552nMAssay Description:Effective concentration for human progesterone receptor in T47D human breast cancer cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129159(9-bromo-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,...)
Affinity DataIC50: 485nMAssay Description:Inhibition of human progesterone receptor activation in T47D human breast cancer cell.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129159(9-bromo-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,...)
Affinity DataKi:  15nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129159(9-bromo-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed