BDBM50129158 7-Fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline::CHEMBL63610

SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4c(F)cccc-34)c12

InChI Key InChIKey=HESOWFNPBNZKMX-UHFFFAOYSA-N

Data  2 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50129158   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129158(7-Fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataEC50:  118nMAssay Description:Antagonistic activity at human progesterone receptor in CV-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129158(7-Fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataKi:  245nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129158(7-Fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataKi:  248nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129158(7-Fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataIC50: 368nMAssay Description:Inhibition of human progesterone receptor activation in T47D human breast cancer cell.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129158(7-Fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataEC50: >1.00E+3nMAssay Description:Effective concentration for human progesterone receptor in T47D human breast cancer cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed