BDBM50129157 (Z)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline::5-sec-Butylidene-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL62981

SMILES CC\C(C)=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key InChIKey=WLEYQRHXERCYNY-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50129157   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129157(5-sec-Butylidene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataIC50: 324nMAssay Description:Antagonist activity at glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129157(5-sec-Butylidene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity against human Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129157(5-sec-Butylidene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataEC50:  11nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129157(5-sec-Butylidene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129157(5-sec-Butylidene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataKi:  8nMAssay Description:Binding affinity for human progesterone receptor; Not activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed