BDBM50129146 (Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline::5-Bromomethylene-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL62700

SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/Br)c3c12

InChI Key InChIKey=NGNZPJWDMRRGGD-UHFFFAOYSA-N

Data  2 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50129146   

TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146(5-Bromomethylene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at mineralocorticoid receptor (hMR); not activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146(5-Bromomethylene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity against Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146(5-Bromomethylene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at glucocorticoid (hGR) receptor; not activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146(5-Bromomethylene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataEC50:  2.20nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146(5-Bromomethylene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against human Estrogen receptor; not activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146(5-Bromomethylene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity for human progesterone receptor; Not activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146(5-Bromomethylene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed