BDBM50129057 (((S)-Hydroxycarbamoyl)-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-methyl)-carbamic acid tert-butyl ester::CHEMBL303983

SMILES Cc1cc(COc2ccc(cc2)N2CC[C@H]([C@H](NC(=O)OC(C)(C)C)C(=O)NO)C2=O)c2ccccc2n1

InChI Key InChIKey=LJHSZEIWFDSULF-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50129057   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129057((((S)-Hydroxycarbamoyl)-{(R)-1-[4-(2-methyl-quinol...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of TNF-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129057((((S)-Hydroxycarbamoyl)-{(R)-1-[4-(2-methyl-quinol...)
Affinity DataIC50: 420nMAssay Description:Inhibition of TNF-alpha production from LPS stimulated human whole blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129057((((S)-Hydroxycarbamoyl)-{(R)-1-[4-(2-methyl-quinol...)
Affinity DataKi:  291nMAssay Description:In vitro inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129057((((S)-Hydroxycarbamoyl)-{(R)-1-[4-(2-methyl-quinol...)
Affinity DataKi:  324nMAssay Description:In vitro inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129057((((S)-Hydroxycarbamoyl)-{(R)-1-[4-(2-methyl-quinol...)
Affinity DataKi:  788nMAssay Description:In vitro inhibition of Matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed