BDBM50129054 (S)-2-{(S)-3-Amino-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-pentanoic acid hydroxyamide::CHEMBL417411

SMILES CCC[C@H](C(=O)NO)[C@@]1(N)CCN(C1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1

InChI Key InChIKey=JTEKRZIXTMGGJR-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50129054   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129054((S)-2-{(S)-3-Amino-1-[4-(2-methyl-quinolin-4-ylmet...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of TNF-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129054((S)-2-{(S)-3-Amino-1-[4-(2-methyl-quinolin-4-ylmet...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of TNF-alpha production from LPS stimulated human whole blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129054((S)-2-{(S)-3-Amino-1-[4-(2-methyl-quinolin-4-ylmet...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129054((S)-2-{(S)-3-Amino-1-[4-(2-methyl-quinolin-4-ylmet...)
Affinity DataKi: >3.00E+3nMAssay Description:In vitro inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129054((S)-2-{(S)-3-Amino-1-[4-(2-methyl-quinolin-4-ylmet...)
Affinity DataKi: >5.00E+3nMAssay Description:In vitro inhibition of Matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed