BDBM50129046 (S)-2-Amino-2-{(R)-1-[4-(2,6-dimethyl-pyridin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-N-hydroxy-acetamide::CHEMBL303510

SMILES Cc1cc(COc2ccc(cc2)N2CC[C@H]([C@H](N)C(=O)NO)C2=O)cc(C)n1

InChI Key InChIKey=QFBSFEVNNJBNOX-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50129046   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129046((S)-2-Amino-2-{(R)-1-[4-(2,6-dimethyl-pyridin-4-yl...)
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of TNF-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129046((S)-2-Amino-2-{(R)-1-[4-(2,6-dimethyl-pyridin-4-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TNF-alpha production from LPS stimulated human whole blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129046((S)-2-Amino-2-{(R)-1-[4-(2,6-dimethyl-pyridin-4-yl...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129046((S)-2-Amino-2-{(R)-1-[4-(2,6-dimethyl-pyridin-4-yl...)
Affinity DataKi: >3.00E+3nMAssay Description:In vitro inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129046((S)-2-Amino-2-{(R)-1-[4-(2,6-dimethyl-pyridin-4-yl...)
Affinity DataKi: >5.00E+3nMAssay Description:In vitro inhibition of Matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed