BDBM50129043 CHEMBL291884::[{(R)-1-[4-(2,6-Dimethyl-pyridin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-((S)-hydroxycarbamoyl)-methyl]-carbamic acid tert-butyl ester

SMILES Cc1cc(COc2ccc(cc2)N2CC[C@H]([C@H](NC(=O)OC(C)(C)C)C(=O)NO)C2=O)cc(C)n1

InChI Key InChIKey=FGGOECPJNJCERE-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50129043   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129043([{(R)-1-[4-(2,6-Dimethyl-pyridin-4-ylmethoxy)-phen...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibition of TNF-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129043([{(R)-1-[4-(2,6-Dimethyl-pyridin-4-ylmethoxy)-phen...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of TNF-alpha production from LPS stimulated human whole blood.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129043([{(R)-1-[4-(2,6-Dimethyl-pyridin-4-ylmethoxy)-phen...)
Affinity DataKi:  2.24E+3nMAssay Description:In vitro inhibition of Matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129043([{(R)-1-[4-(2,6-Dimethyl-pyridin-4-ylmethoxy)-phen...)
Affinity DataKi: >3.00E+3nMAssay Description:In vitro inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed