BDBM50128538 5-[7-Methoxy-4-(3-nitro-phenyl)-3,4-dihydro-1H-isoquinolin-2-ylmethyl]-pyrimidine-2,4-diamine::CHEMBL78104

SMILES COc1ccc2C(CN(Cc3cnc(N)nc3N)Cc2c1)c1cccc(c1)[N+]([O-])=O

InChI Key InChIKey=SZNFKQXJHREVCC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50128538   

TargetDihydrofolate reductase(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128538(5-[7-Methoxy-4-(3-nitro-phenyl)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 56nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128538(5-[7-Methoxy-4-(3-nitro-phenyl)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 6nMAssay Description:Antibacterial activity of TMP-susceptible Dihydrofolate reductase against Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus (strain MW2))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128538(5-[7-Methoxy-4-(3-nitro-phenyl)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibitory activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus aureus 157/4696More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128538(5-[7-Methoxy-4-(3-nitro-phenyl)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antibacterial activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed