BDBM50128530 5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidine-2,4-diamine::CHEMBL74781

SMILES COc1cc2CCN(Cc3cnc(N)nc3N)C(C)c2cc1OC

InChI Key InChIKey=CUCBSCJBDZZPNK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50128530   

TargetDihydrofolate reductase(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50: 44nMAssay Description:Antibacterial activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50: 670nMAssay Description:Antibacterial activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus (strain MW2))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus aureus 157/4696More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50: 53nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed