BDBM50126926 CHEMBL3628835::US10351558, Example 183

SMILES Cc1ncn(n1)-c1ccc(C(=O)N[C@@]2(CCc3c(CCC(O)=O)c4cc(C)ccc4n3C2)c2ccccc2)c(Cl)c1

InChI Key InChIKey=KPJWUKSEMFQHIW-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50126926   

TargetCoagulation factor IX(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50126926(CHEMBL3628835 | US10351558, Example 183)
Affinity DataIC50: 2.69nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
Go to US Patent

TargetCoagulation factor IX(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50126926(CHEMBL3628835 | US10351558, Example 183)
Affinity DataKi:  2.70nMAssay Description:Inhibition of human F9a using CH3SO2-D-CHG-Gly-Arg-AFC.AcOH as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126926(CHEMBL3628835 | US10351558, Example 183)
Affinity DataKi:  4.23E+3nMAssay Description:Inhibition of human F10a using CH3SO2-D-CHG-Gly-Arg-AFC.AcOH as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed