BDBM50126711 CHEMBL28374::Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-[4-(4-methoxy-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester

SMILES COc1ccc(cc1)N1CCN(CC1)C(=O)[C@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)N(C)S(=O)(=O)c1cccc2cnccc12

InChI Key InChIKey=XSRFYANYQOKBJT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50126711   

TargetP2X purinoceptor 7(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50126711(Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoli...)
Affinity DataIC50: 132nMAssay Description:Antagonistic activity against P2X7 receptor measured as the ATP dependent calcium influx in human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50126711(Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoli...)
Affinity DataIC50: 132nMAssay Description:Antagonist activity at P2X7 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed