BDBM50126419 CHEMBL282342::N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin-5-yl]-butane-1,4-diamine::N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5-yl)butane-1,4-diamine

SMILES CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCCN)n1

InChI Key InChIKey=SBGMPUIVPOGTGN-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50126419   

TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126419(N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin...)
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against spleen tyrosine kinase (SYK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50126419(N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin...)
Affinity DataKd:  395nMAssay Description:Binding affinity to human TXKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50126419(N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin...)
Affinity DataKd:  623nMAssay Description:Binding affinity to human SLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLysine--tRNA ligase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50126419(N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin...)
Affinity DataIC50: 34nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126419(N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin...)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126419(N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin...)
Affinity DataIC50: 19nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed