BDBM50126186 2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic acid::CHEMBL27323

SMILES C/C(=C\C(=O)Nc1ccccc1C(=O)O)/c2ccc3ccccc3c2

InChI Key InChIKey=PGFQXGLPJUCTOI-UHFFFAOYSA-N

Data  13 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50126186   

TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against telomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 280nMAssay Description:Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2016
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 410nMAssay Description:Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 170nMAssay Description:Inhibition of telomerase in human MDA-MB-231 cells after 24 hrs by TRAP-PCR-ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 93nMAssay Description:Inhibition of human telomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 93nMAssay Description:Inhibition of telomerase in human HeLa cells after 2 hrs by [alpha-32P]dGTP incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 93nMAssay Description:Inhibition of human telomerase isolated from human HeLa cells nuclear extracts expressed in insect cells assessed as [33P]dCMP incorporation after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 280nMAssay Description:Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human telomerase activity isolated from HEK293 cells assessed as reduction in dNTP incorporation using 5'-biotinylated AATCCGTCGAGCAGAG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2019
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant His-tagged human telomerase expressed in insect cells preincubated for 15 mins followed by dNTPs and oligonucleotide primer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed