BDBM50126158 3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-5'-yl)benzonitrile::CHEMBL28157

SMILES Fc1cc(cc(c1)-c1ccc2NC(=S)C3(CCCCC3)c2c1)C#N

InChI Key InChIKey=HJOUYAMEBCDGKK-UHFFFAOYSA-N

Data  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50126158   

TargetAndrogen receptor(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against Androgen receptor in mouse fibroblast L929 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against glucocorticoid receptor in human lung A549 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataIC50: 16nMAssay Description:Inhibition of 3 nM [3H]R5020 binding to progesterone receptor in human T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataEC50:  0.360nMAssay Description:Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataIC50: 35nMAssay Description:Inhibitory activity against glucocorticoid receptor in human lung A549 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataIC50: 7.43nMAssay Description:Inhibitory progestational activity on oral administration in uterine C3 modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against Androgen receptor in mouse fibroblast L929 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed