BDBM50126042 4-[3-(5-Chloro-3'-methoxy-biphenyl-2-yl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile::CHEMBL26068

SMILES COc1cccc(c1)-c1cc(Cl)ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N

InChI Key InChIKey=HRCUJSFALQORGR-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50126042   

LigandPNGBDBM50126042(4-[3-(5-Chloro-3'-methoxy-biphenyl-2-yl)-1-hydroxy...)
Affinity DataEC50:  4nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50126042(4-[3-(5-Chloro-3'-methoxy-biphenyl-2-yl)-1-hydroxy...)
Affinity DataIC50: 740nMAssay Description:Inhibition of human GGTase-catalyzed incorporation of [3H]GGPP into biotinylated peptide of C-terminal of human K-RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50126042(4-[3-(5-Chloro-3'-methoxy-biphenyl-2-yl)-1-hydroxy...)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of human FTase-catalyzed incorporation of [3H]FPP into recombinant Ras CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed