BDBM50126026 3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-benzonitrile::CHEMBL25620

SMILES Cn1cncc1C(O)(C#Cc1ccc(cc1-c1ccc2OCOc2c1)C#N)c1ccc(cc1)C#N

InChI Key InChIKey=RXGGZGACWDLIGX-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50126026   

TargetGeranylgeranyl transferase type-1 subunit beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50126026(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-phenyl)-3-hy...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human GGTase-catalyzed incorporation of [3H]GGPP into biotinylated peptide of C-terminal of human K-RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50126026(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-phenyl)-3-hy...)
Affinity DataEC50:  1.40nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50126026(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-phenyl)-3-hy...)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of human FTase-catalyzed incorporation of [3H]FPP into recombinant Ras CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed