BDBM50125936 3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid 2-(3-methyl-3H-diazirin-3-yl)-ethyl ester::CHEMBL23497

SMILES C[C@H](c1ccccc1)n1cncc1C(=O)OCCC1(C)N=N1

InChI Key InChIKey=DUOHNSBKYJHAMQ-UHFFFAOYSA-N

Data  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50125936   

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataEC50:  3.70E+4nMAssay Description:Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataEC50:  2.00E+3nMAssay Description:Enhancement of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataEC50:  1.20E+3nMAssay Description:Ability to enhance currents from alpha-1-beta-2-gamma-2L-subunit of GABA receptor elicited by low concentrations of GABAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed