BDBM50124932 5-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one::CHEMBL351963

SMILES Cc1ccc(CN2CCN(CC2)C2CCc3cccc4CCN(c34)C2=O)cc1

InChI Key InChIKey=VKKGUQYWMBPDPR-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50124932   

TargetD(4) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124932(5-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  4nMAssay Description:D4 receptor functional activity was measured inhibition of quinpirole stimulated [35S]GTP-gamma-S binding from cell membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124932(5-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  4nMAssay Description:Binding affinity to D4R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124932(5-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  209nMAssay Description:D2 receptor functional activity was measured through reversal of quinpirole inhibited, forskolin stimulated cAMP production from whole cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124932(5-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  209nMAssay Description:Binding affinity to D2R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50124932(5-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  1.36E+3nMAssay Description:Displacement of [3H]prazosin from alpha-1 adrenergic receptor of rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed