BDBM50124908 CHEMBL159560::N-(2-Methoxy-benzyl)-4-trifluoromethoxy-benzamidine

SMILES COc1ccccc1CN=C(N)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=BOWYULWXOYQNDI-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50124908   

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124908(N-(2-Methoxy-benzyl)-4-trifluoromethoxy-benzamidin...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of the response to NMDA glutamate/glycine receptor NR2B subtype was determined using FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50124908(N-(2-Methoxy-benzyl)-4-trifluoromethoxy-benzamidin...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]ifenprodil from Wistar rat GluN2B receptor after 2 hrs by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124908(N-(2-Methoxy-benzyl)-4-trifluoromethoxy-benzamidin...)
Affinity DataKi:  5.70nMAssay Description:Displacement of NMDA receptor-specific [3H]ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed