BDBM50124705 CHEMBL3622924

SMILES Cc1cn(cc1CN1CC[C@@H](O)C1)-c1ccnc(Nc2cc(C)cc(C)c2)n1

InChI Key InChIKey=APIGRKGHKBCGNE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50124705   

TargetCytochrome P450 3A4(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124705(CHEMBL3622924)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124705(CHEMBL3622924)
Affinity DataIC50: 77nMAssay Description:Inhibition of SYK-mediated TNFalpha production in human IgG-stimulated human THP1 cells incubated for 18 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124705(CHEMBL3622924)
Affinity DataIC50: 1.15E+5nMT: 2°CAssay Description:Inhibition of human JAK2 pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate addition by cell f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124705(CHEMBL3622924)
Affinity DataIC50: 349nMT: 2°CAssay Description:Inhibition of JAK3 (unknown origin) pre-incubated for 30 mins at room temperature before substrate addition and measured 1 hr after substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50124705(CHEMBL3622924)
Affinity DataIC50: 2.30nMT: 2°CAssay Description:Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed