BDBM50124606 5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL267940

SMILES CC1=CC(C)(C)Nc2ccc-3c(C(CC=C)Oc4cccc(C=C)c-34)c12

InChI Key InChIKey=CPUIRDMVUBPAPK-UHFFFAOYSA-N

Data  3 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50124606   

TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataEC50:  12nMAssay Description:Transcriptional repression in HepG2 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of concanavalin A stimulated T-cell proliferation in human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataEC50:  17nMAssay Description:Transcriptional activation in CV-1 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataEC50:  90nMAssay Description:Inhibition of concanavalin A stimulated rat splenocyte proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]dexamethasone as radioligand in SF-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataKi:  239nMAssay Description:Binding affinity towards testosterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataKi:  435nMAssay Description:Displacement of [3H]progesterone from human Progesterone receptor AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed