BDBM50124097 CHEMBL422387::N-(1H-Indol-5-ylmethyl)-2-(6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-acetamide

SMILES Cc1cnc(NCCc2ccccc2)c(=O)n1CC(=O)NCc1ccc2[nH]ccc2c1

InChI Key InChIKey=LJKDPVVOUWUHCQ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50124097   

TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124097(N-(1H-Indol-5-ylmethyl)-2-(6-methyl-2-oxo-3-phenet...)
Affinity DataKi:  18nMAssay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124097(N-(1H-Indol-5-ylmethyl)-2-(6-methyl-2-oxo-3-phenet...)
Affinity DataKi:  18nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124097(N-(1H-Indol-5-ylmethyl)-2-(6-methyl-2-oxo-3-phenet...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124097(N-(1H-Indol-5-ylmethyl)-2-(6-methyl-2-oxo-3-phenet...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed