BDBM50123519 2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid 2,4-difluoro-benzylamide::CHEMBL148342

SMILES COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1

InChI Key InChIKey=IXKPEYHRIVQTCU-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50123519   

TargetPotassium voltage-gated channel subfamily A member 5(Human)
Aventis Pharma Deutschland

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 7nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human TASK1 expressed in CHO cells by Inside-out macro-patches based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 5(Human)
Universidad De Talca

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human TASK2 expressed in CHO cells by Inside-out macro-patches based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 17(Human)
Universidad De Talca

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human TASK4 expressed in CHO cells by Inside-out macro-patches based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human TASK1 expressed in Xenopus oocytes by whole cell voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 9(Human)
Universidad De Talca

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 318nMAssay Description:Inhibition of human TASK3 expressed in Xenopus oocytes by whole cell voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 9(Human)
Universidad De Talca

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human TASK3 expressed in CHO cells by Inside-out macro-patches based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 9(Rat)
Universidad De Talca

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 36nMAssay Description:Inhibition of rat TASK3 expressed in (FRT) epithelial cells by chamber based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human TASK-1 expressed in Xenopus laevis oocytes assessed as inhibition of channel current at +40mV holding potential by two-electrode ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed