BDBM50123468 CHEMBL32865::[3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2-ylmethyl)-phenyl]-(8-hydroxy-[1,6]naphthyridin-7-yl)-methanone::[3-Benzyl-5-(1,1-dioxo-1lambda*6*-isothiazolidin-2-ylmethyl)-phenyl]-(8-hydroxy-[1,6]naphthyridin-7-yl)-methanone::[3-benzyl-5-(1,1-dioxo-1lambda-6-isothiazolidin-2-ylmethyl)-phenyl]-(8-hydroxy-[1,6]naphthyridin-7-yl)-methanone

SMILES Oc1c(ncc2cccnc12)C(=O)c1cc(CN2CCCS2(=O)=O)cc(Cc2ccccc2)c1

InChI Key InChIKey=UMPCIKHDGHZMJR-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50123468   

TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123468([3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2...)
Affinity DataIC50: 10nMAssay Description:Compound was tested for its ability to inhibit the strand transfer of the integration process catalyzed by HIV integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123468([3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2...)
Affinity DataEC50: >800nMAssay Description:Potency of compound was tested against HIV-1- containing integrase mutations (T66I, S153Y)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123468([3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2...)
Affinity DataEC50:  140nMAssay Description:Potency of compound was tested against HIV-1- containing integrase mutations (NL4-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123468([3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against integrase-catalysed strand transferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123468([3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Fondazione Cenci Bolognettiuniversit£

Curated by ChEMBL
LigandPNGBDBM50123468([3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity by high throughput electrochemiluminescent assay in presence of magnesiumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Fondazione Cenci Bolognettiuniversit£

Curated by ChEMBL
LigandPNGBDBM50123468([3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123468([3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2...)
Affinity DataIC50: 10nMAssay Description:Inhibition of HIV-1 integrase DTG-resistant R263K mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed