BDBM50123364 CHEMBL3622696

SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1cccc(CCc2ccncc2)c1

InChI Key InChIKey=LXLOKEPIZACOOX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50123364   

TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50123364(CHEMBL3622696)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50123364(CHEMBL3622696)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50123364(CHEMBL3622696)
Affinity DataIC50: 4.24E+5nMAssay Description:Inhibition of human SIRT1 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50123364(CHEMBL3622696)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of human SIRT2 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed