BDBM50123268 4-Dimethylamino-2,2-diphenyl-butyronitrile::CHEMBL346898

SMILES CN(C)CCC(C#N)(c1ccccc1)c1ccccc1

InChI Key InChIKey=SZOCKYDZSPRJPT-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50123268   

TargetSodium-dependent dopamine transporter(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50123268(4-Dimethylamino-2,2-diphenyl-butyronitrile | CHEMB...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of reuptake of DA into striatal nerve endings (synaptosomes)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50123268(4-Dimethylamino-2,2-diphenyl-butyronitrile | CHEMB...)
Affinity DataKi:  3.91E+3nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50123268(4-Dimethylamino-2,2-diphenyl-butyronitrile | CHEMB...)
Affinity DataKi:  1.61E+4nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50123268(4-Dimethylamino-2,2-diphenyl-butyronitrile | CHEMB...)
Affinity DataKi:  1.79E+4nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50123268(4-Dimethylamino-2,2-diphenyl-butyronitrile | CHEMB...)
Affinity DataKi:  2.32E+4nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed