BDBM50122588 4-Methoxy-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide::CHEMBL326280

SMILES COCC#CC(=O)Nc1cc2c(Nc3cccc(Br)c3)c(cnc2cc1OC)C#N

InChI Key InChIKey=JWORJWFEXVTKPW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50122588   

TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122588(4-Methoxy-but-2-ynoic acid [4-(3-bromo-phenylamino...)
Affinity DataIC50: 790nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122588(4-Methoxy-but-2-ynoic acid [4-(3-bromo-phenylamino...)
Affinity DataIC50: 790nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50122588(4-Methoxy-but-2-ynoic acid [4-(3-bromo-phenylamino...)
Affinity DataIC50: 380nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122588(4-Methoxy-but-2-ynoic acid [4-(3-bromo-phenylamino...)
Affinity DataIC50: 794nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122588(4-Methoxy-but-2-ynoic acid [4-(3-bromo-phenylamino...)
Affinity DataIC50: 7.91E+5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article