BDBM50122564 (E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-quinolin-6-yl]-amide::4-Morpholin-4-yl-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-quinolin-6-yl]-amide::CHEMBL118000

SMILES Fc1ccc(Nc2c(cnc3ccc(NC(=O)\C=C\CN4CCOCC4)cc23)C#N)cc1Cl

InChI Key InChIKey=USKFPOBBUSZDCR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50122564   

TargetEpidermal growth factor receptor(Human)
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122564((E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-chloro...)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of epidermal growth factor receptor kinase (unknown origin) using [33P]-ATP after 20 to 30 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122564((E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-chloro...)
Affinity DataIC50: 2.29E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122564((E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-chloro...)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50122564((E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-chloro...)
Affinity DataIC50: 8.74E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122564((E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-chloro...)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122564((E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-chloro...)
Affinity DataIC50: 2.29E+6nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article